The joint pain can vary from mild to be very debilitating, and may last from a few days to many months or years, depending on the strain. Several neurological manifestations, including Guillain-Barré syndrome (GBS), are associated with ZIKV, DENV or CHIKV [3–5]. Other less frequent symptoms: Joint swelling; Nausea/vomit; Conjunctivitis Photophobia; Fatigue; Sore Throat; Chikungunya disease is very rarely fatal, but the virus sometimes causes serious complications, mostly in older people, babies or people with underlying medical conditions. Investigation, From eight ZIKV+ cases, four were identified by RT-qPCR (two from serum and two from urine samples) and four were identified by IgM, of which six were DENV- and CHIKV-. As long as the number of the aegypti mosquitoes remains low, there is very little likelihood the mosquitoes found in Shasta County will carry zika, yellow fever, dengue or chikungunya, Bonkrude said. The majority of people infected with Zika virus have no symptoms. If necessary, patients were sent to a third−level−care hospital. In contrast, two of the eight case-control studies previously mentioned did not demonstrate any association [21,26]. No association between GBS and CHIKV infection was found, nor were co-infections demonstrated among these three viruses. Differentiating Between Malaria, Dengue, and Chikungunya Understand that the diseases are … Symptoms may include: Symptoms can appear two to 15 days after being bitten by an infected mosquito. We have only taken into account the eight published case and control studies for the purpose of discussion for this paper, in spite of the comments published point out their limitations, such as: lack of precision in the clinical and differential diagnoses, flaws in the methodological design, biases and statistical limitations. Data curation, Supervision, Le chikungunya, la dengue et le zika sont des maladies à transmission vectorielle. Hospital General de Zona No. Most patients feel better within a week. La plupart des patients se rétablissent complètement, mai… Data curation, Mother to Infant: Since the virus is present in the blood, there is a risk for congenital transmission from a pregnant woman to her baby during pregnancy. Supervision, Affiliation No, Is the Subject Area "Chikungunya virus" applicable to this article? The small sample size obtained for an epidemiological study due to the lack of participation of the institution epidemiologists, which prevented identifying more ZIKV, DENV, or CHIKV cases related to GBS. Interestingly, both AMAN and AIDP cases were found in Northeastern Mexico [27]. Primary Health-Care Unit. In 2016, Cao-Lormeau et al. Signs and symptoms suggestive of Zika virus infection may include a combination of the following: 1. rash 2. itching or pruritus 3. fever 4. headache 5. arthralgia or arthritis 6. myalgia 7. Methodology, The present study results show an association between GBS and ZIKV, as well as between GBS and ZIKV/DENV, both flaviviruses, supported by laboratory analysis. Finally, the symptoms of suspected ZIKV disease prior to the development of GBS were similar to some previous reports. Le chikungunya, la dengue et le zika sont des maladies à transmission vectorielle. In this work, symptoms prior to the development of GBS related to the symptoms of ZIKV suspected disease, such as rash, fever and conjunctivitis, showed significant differences to controls. After an infected mosquito bites a human, the first symptoms of Zika can develop in 3 to 12 days but it can be shorter or longer in some people. The following definitions were established to determine the type of ZIKV, DENV or CHIKV infection: Acute infection by ZIKV, DENV, or CHIKV was defined as a positive result to the reverse transcriptase real-time polymerase chain reaction (RT-qPCR) in either serum or urine samples for ZIKV, or positive serum samples for DENV or CHIKV as follows: Laboratory evidence of ZIKV, DENV or CHIKV infection was defined as a positive ZIKV, DENV, or CHIKV RT-qPCR result in serum or urine samples, or an anti-ZIKV, anti-DENV or anti-CHIKV immunoglobulin M (IgM) detected in serum as follows: Diagnostic tests were performed at the Central Laboratory of Epidemiology, La Raza National Medical Center, IMSS, Mexico City, following the epidemiological surveillance guidelines and in compliance with the national regulations established by the Mexican Ministry of Health. … e0008032. Patients were evaluated by a neurologist, who diagnosed GBS based on the clinical features and neurological manifestations of the disease, as well as cerebrospinal fluid (CSF) analysis and electrodiagnostic test results, in keeping with international criteria [14]. The mean age of patients with GBS and controls was 39 ± 19.3 years and 39.7 ± 18.5 years, respectively. Is the Subject Area "Guillain-Barre syndrome" applicable to this article? The most common symptoms are fever and joint pain. species also spread Dengue and Chikungunya, which can cause symptoms similar to Zika. Conceptualization, https://doi.org/10.1371/journal.pntd.0008032, Editor: Maya Williams, Naval Medical Research Center, UNITED STATES, Received: December 30, 2019; Accepted: October 5, 2020; Published: December 17, 2020. Positive ZIKV, DENV, or CHIKV results: co-infection. Because these three arboviruses coexist in Mexico, the frequency and severity of GBS could theoretically increase. In the case of ZIKV, primers and probes were used to amplify the coding region of protein E as previously reported [15]. 2018 Jul; 12(7):e0006533. Chikungunya is a mosquito-borne viral disease first described during an outbreak in southern Tanzania in 1952. Writing – review & editing, Affiliation The study shows a positive association between GBS cases and ZIKV or ZIKV and DENV infection. Writing – original draft, Roles Supervision, Similar to previous studies, the present report also demonstrated that GBS cases associated with ZIKV showed a more severe clinical picture [12,13], which should be considered for the treatment of these patients in countries where previous ZIKV infection could lead to this neurological disease. Cases of GBS associated with ZIKV demonstrated a greater impairment of functional status and a higher percentage of mechanical ventilation. Symptoms usually begin 3–7 days after being bitten by an infected mosquito. The grant was obtained by IG. 03038505001, Roche Diagnostic, Basel, Switzerland) following the manufacturer's recommendations. Funding acquisition, These findings agree with those previously reported by Salinas et al. The dengue infection can be asymptomatic (up to 40% to 80%), mild or cause a serious illness, which in extreme cases can cause death. 2017. Other signs and symptoms may include headache, red eyes (conjunctivitis) and a general feeling of discomfort. There is currently no vaccine to prevent or medicine to treat chikungunya virus. We investigated dengue and chikungunya virus antibody seroprevalence in French Polynesia during 2014–2015. le chikungunya, la dengue ou le zika. Conceptualization, Other clinical outcomes of GBS patients are shown in Table 4. https://doi.org/10.1371/journal.pntd.0008032.t004. Le moustique Aedes albopictus est un moustique d'origine tropicale, également appelé moustique tigre. Patients who met levels 1–3 of diagnostic certainty according to the Brighton Collaboration criteria were considered as eligible and were invited to participate in the protocol. 11. GBS associated with ZIKV is often related to dysautonomia, paralysis of cranial nerves and more rapid onset of signs and symptoms [20,21]. The limitations of this study are the following: In conclusion, the present study demonstrates laboratory evidence of ZIKV infection associated with GBS as well as laboratory evidence of the association of GBS with both ZIKV and DENV (flavivirus) infection. 36, Instituto Mexicano del Seguro Social, Coatzacoalcos, Veracruz, Mexico. Controls were matched by age, gender and place of residence. Les autres signes et symptômes communs sont notamment myalgies, céphalées, nausée, fatigue et éruption. Formal analysis, in French Polynesia, demonstrating the association between GBS and ZIKV for the first time [9]. There is no cure for these virus diseases, the treatment consists on relieving the symptoms and a proper clinical management can improve outcome. La période d'incubation pour le chikungunya est de dix jours; en règle générale, les premiers symptômes du virus apparaissent même dans les cinq jours qui suivent la contamination.Les données sont similaires pour les symptômes de la dengue qui vont se manifester de cinq à huit jours après piqûre du moustique tigre.. Une fois ces délais passés, voici selon les explications … View Article The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Chikungunya is characterized by an abrupt onset of fever frequently accompanied by joint pain. By contrast, it was more common in the present work (42.9%). It is rare for a mother infected with Zika around the time of delivery to pass the virus on to the infant. The main clinical signs and symtoms were fever (51.2%), headache (78%), chills (6.1%), pruritus (12.2%), exanthema (20.1%), According to laboratory results, an association between ZIKV or ZIKV and DENV infection in patients with GBS was found. GBS cases associated with ZIKV depicted a more severe clinical picture (more impairment of functional status, incapacity, and a higher percentage of mechanical ventilation). CHIKUNGUNYA: Chikungunya (CHIK) fever is a viral disease characterised by a sudden fever accompanied by skin rashes and joint pain, followed by persistent rheumatic symptoms. The recent emergence and re-emergence of viral infections transmitted by vectors—Zika, chikungunya, dengue, Japanese encephalitis, West Nile, yellow fever and others—is a cause for international concern. Zika is usually mild with symptoms lasting for several days to a week. [24] and Simon et al. Hence the virus can cause acute, subacute or chronic disease. Hospital General Regional No.1, Instituto Mexicano del Seguro Social Orizaba, Veracruz, Mexico, Affiliation The detection of RNA from ZIKV, CHIKV and DENV was carried out by RT-qPCR, using the uniplex or triplex format. No, Is the Subject Area "Dengue virus" applicable to this article? Investigation, We know that these three arboviruses have coexisted in Mexico since 2015. Writing – original draft, Roles On the contrary, these results differ from other regions of Asia, including Bangladesh and the Americas (Cúcuta and Barranquilla, in Colombia) as well, in which the demyelinating type AIDP subtype was the most frequent [21,23,26]. Once a person has been infected, he or she is likely to be protected from future infections of the same virus. Most of the infections remain asymptomatic (approximately 80%); L'arthralgie est souvent invalidante, mais elle disparaît généralement au bout de quelques jours ou de quelques semaines. No, PLOS is a nonprofit 501(c)(3) corporation, #C2354500, based in San Francisco, California, US, https://doi.org/10.1371/journal.pntd.0008032. Many symptoms of chikungunya are similar to dengue and zika. Chikungunya is a virus that spread by the same kinds of mosquitoes that spread dengue and Zika virus.Rarely, it can spread from mother to newborn around the time of birth. Males were predominant in both groups (59/87 and 113/184, respectively), representing 61% of the total participants. 33, Instituto Mexicano del Seguro Social, Monterrey, Nuevo León, Mexico, Roles Formal analysis, The uniplex RT-qPCR assays to detect DENV were performed with the QuantiTect Probe RT-PCR Kit (Cat. Suspected case symptoms of ZIKV before the development of GBS in ZIKV+ cases, such as rash, fever and conjunctival hyperemia, were more frequent and significantly different than controls.