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Accueil du site > Équipes > Molécules Bioactives > Thème Ligands d’Acides Nucléiques (Targeting of Nucleic Acids research group)
Thème Ligands d’Acides Nucléiques (Targeting of Nucleic Acids research group)
Introduction
Maria DUCA research group
Member of COST Epichembio (CM1406)
RNA represents a major biological target for future drug development, because it is involved in a wide number of biological processes, such as transcription, translation or catalysis and more importantly it is essential for the regulation of gene expression. Most biologically relevant RNAs bear a three-dimensional structure containing single-stranded regions (loops and bulges) associated to double-stranded regions that offers the possibility for selective/specific binding interactions with proteins and small-molecule ligands. The main goal of our research activities is to design and synthesize new RNA ligands bearing both strong affinity and high selectivity for a biologically relevant RNA target and to study the interactions involved in the formation of the ligand-RNA complex using biochemical and biophysical techniques.
