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Thème Ligands d’Acides Nucléiques (Targeting of Nucleic Acids research group)



  • Staedel, C., Tran, T.P.A., Giraud, J., Darfeuille, F., Di Giorgio, A., Tourasse, N.J., Salin, F., Uriac, P., Duca, M. Modulation of oncogenic miRNA biogenesis using functionalized polyamines Scientific Reports 2018 Just Accepted


  • Vo, D.D., Duca, M. Design of multimodal small molecules targeting miRNAs biogenesis : synthesis and in vitro evaluation Methods Mol. Biol. 2017 1517, 137.
  • Duca, M. Interfering with Enzymatic steps of microRNAs pathway using small molecules in Advances in Studies on Enzyme Inhibitors as Drugs Ed. Novascience 2017 vol.1, p.83.


  • D.D. Vo, T.P.A. Tran, C. Staedel, R. Benhida, A. Di Giorgio, M. Duca (2016) Oncogenic microRNAs biogenesis as a drug target : structure-activity relationship studies on novel aminoglycoside conjugates Chem. Eur. J. 22, 5350-5362.
  • D.D. Vo, M. Duca (2016) Design of multimodal small molecules targeting miRNAs biogenesis : synthesis and in vitro evaluation Methods Mol. Biol. Sous presse
  • A. Di Giorgio, T. P. A. Tran, M. Duca (2016) Small-molecule approaches toward the targeting of oncogenic microRNAs : roadmap for the discovery of RNA modulators, Future Medicinal Chemistry, 8, 803-816.


  • T.P.A. Tran, D.D. Vo, A. Di Giorgio, M. Duca (2015) Ribosome-targeting antibiotics as inhibitors of oncogenic microRNAs biogenesis : Old scaffolds for new perspectives in RNA targeting. Bioorg. Med. Chem. 23, 5334-5344
  • L. Pascale, A. López González, A. Di Giorgio, M. Gaysinski, J. Teixido Closa, R. Estrada Tejedor, S. Azoulay, N. Patino (2015) Deciphering structure-activity relationships in a series of Tat/TAR inhibitors. J. Biomol. Struct. Dyn.


  • D.D. Vo, C. Staedel, L. Zehnacker, R. Benhida, F. Darfeuille, M. Duca (2014) Targeting the production of oncogenic microRNAs with multimodal synthetic small molecules. ACS Chem. Biol., 9, 711-21.
  • J.P. Joly, G. Mata, P. Eldin, L. Briant, F. Fontaine-Vive, M. Duca, R. Benhida (2014). Artificial nucleobase-amino acid conjugates : a new class of TAR RNA binding agents. Chem Eur J, 20, 2071-9
  • Rocchi S., Ballotti R., Benhida R., Cerezo M., Duca M., Joly, J.P. Preparation of arylsulfonamido thiazole derivs. as antitumor agents PCT Int. Appl. (2014), WO 2014072486


  • L. Pascale, S. Azoulay, A. Di Giorgio, L. Zenacker, M. Gaysinski, P. Clayette, N. Patino (2013). Thermodynamic studies of a series of homologous HIV-1 TAR RNA ligands reveal that loose binders are stronger Tat competitors than tight ones. Nucleic Acids Res 11, 5851-63 (IF 8.28).
  • C.Y. Darini, P. Martin, S. Azoulay, M.D. Drici, P. Hofman, S. Obba, C. Dani, A. Ladoux (2013). Targeting cancer stem cells expressing an embryonic signature with anti-proteases to decrease their tumor potential. Cell Death Dis 4, E706


  • P. Vekhoff, M. Duca, D. Guianvarc’h, R. Benhida, P.B. Arimondo (2012). Sequence specific base pair mimics are efficient topoisomerase IB inhibitors. Biochemistry, 51, 43-51.
  • G. Upert, A. Di Giorgio, A. Upadhyay, D. Manvar, N. Pandey, V.N. Pandey, N. Patino (2012). Inhibition of HIV Replication by Cyclic and Hairpin PNAs Targeting the HIV-1 TAR RNA Loop. J Nucleic Acids
  • V. Malnuit, M. Duca, R. Benhida (2011). Targeting DNA base pair mismatch with artificial nucleobases. Advances and perspectives in triple helix strategy. Org. Biomol. Chem., 9, 326-36.